Persistence and pathogenesis of the neurotropic polyomavirus JC
نویسندگان
چکیده
منابع مشابه
Persistence and pathogenesis of the neurotropic polyomavirus JC.
Many neurological diseases of the central nervous system (CNS) are underpinned by malfunctions of the immune system, including disorders involving opportunistic infections. Progressive multifocal leukoencephalopathy (PML) is a lethal CNS demyelinating disease caused by the human neurotropic polyomavirus JC (JCV) and is found almost exclusively in individuals with immune disruption, including pa...
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In the last several years, studies have reported the detection of sequences similar to the polyomavirus, Simian Virus 40 (SV40) in human tumors including choroid plexus papillomas and ependymomas. Taken together with well-established evidence that SV40, as well as the human polyomaviruses JC virus (JCV) and BK virus (BKV), are oncogenic in several animal models, new interest has resurfaced rega...
متن کاملPrimary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus, genome.
B lymphocytes are known as a potential site for latency and reactivation of the human neurotropic polyomavirus, JC virus (JCV). In light of recent studies on the oncogenicity of JCV and the transforming ability of the JCV early protein, T antigen, we investigated the association of JCV with B-cell lymphomas of the central nervous system. Examination of 27 well-characterized clinical specimens b...
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Immunostaining and polymerase chain reaction (PCR) methods were used to examine tissues from 18 6-month-old hamsters intracerebrally inoculated with JC virus (JCV) as newborns. JCV DNA was detected in all hamster brains and urinary bladders, as well as in most kidney, adrenal gland and pancreas samples. While results from reverse transcription PCR (RNA PCR) and immunostaining suggest that T ant...
متن کاملNew Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy
John Cunningham virus (JCV) is a member of the Polyomaviridae family. It was first isolated from the brain of a patient with Hodgkin disease in 1971, and since then the etiological agent of the progressive multifocal leukoencephalopathy (PML) was considered. Until the human immunodeficiency virus (HIV) pandemic, PML was rare: in fact HIV-induced immunodeficiency is the most common predisposing ...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2015
ISSN: 0364-5134
DOI: 10.1002/ana.24371